Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT
نویسندگان
چکیده
منابع مشابه
Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT
UNLABELLED BACKGROUND Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, wild-type healthy mice were scanned using 123I-β-CIT. METHODS The pharmaco...
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OF TALK The monoaminergic neurotransmitter dopamine (DA) has been implicated in multiple brain disorders including schizophrenia, attention deficit hyperactivity disorder (ADHD), addiction and Parkinson's disease. Dopamine transporter (DAT) is a major regulator of both the intensity of extracellular dopamine (DA) signaling and presynaptic neuronal homeostasis. By deleting the gene encoding the ...
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OBJECTIVE To investigate dopaminergic function in a large cohort of patients with corticobasal syndrome (CBS) and describe its relationship with clinical features in comparison to Parkinson's disease and healthy control subjects. In addition, we assessed prevalence and features of individuals with CBS and in vivo evidence of preserved nigral neuronal density. BACKGROUND Substantia nigra pars ...
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ژورنال
عنوان ژورنال: EJNMMI Research
سال: 2012
ISSN: 2191-219X
DOI: 10.1186/2191-219x-2-55